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6.2 Applications in anti-infective therapy: targeting intracellular sanctuaries and overcoming drug resistance barriers Numerous pathogens posing severe threats to human health—including specific bacteria, fungi, and parasites—have evolved an ingenious survival strategy: they internalize into host cells (particularly immune cells like macrophages) to establish “intracellular sanctuaries.” Within these protective niches, pathogens evade host circulatory antibodies and complement attacks while resisting antibiotics that fail to penetrate cell membranes effectively, thereby forming persistent “pathogen reservoirs” for recurrent infections (Zhang and Cheng, 2022)

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Lower gut abundance of Eubacterium rectale is linked to COVID-19 mortality